杨宇晨

个人简介

杨宇晨，“百人计划”副教授，硕士生导师

联系方式：yangych68@mail.sysu.edu.cn

实验室网站：https://yuchenyanggroup.github.io/

致力于探究植物代谢和环境适应的机制。我们的目标是了解植物适应环境胁迫（高盐、高温、污染物等）的分子机理，并希望利用这些在特征植物中的发现对生态环境进行保护和修复。具体来讲，我们利用多组学技术（转录组测序、ATAC-seq等）来探究植物中与代谢和胁迫响应相关的基本事件和机制，包括植物激素介导的生理生化过程、重金属离子的吸收和外排等等。另外，我们还开展了与植物节律调节相关的研究，例如探究植物光周期和潮汐节律背后的遗传基础。相关研究成果在Nucleic Acids Research、Briefings in Bioinformatics、Plant Physiology and Biochemistry等国际期刊发表SCI论文50余篇。

研究方向

植物适应极端环境的转录及转录后调控机制

植物响应污染物胁迫的调控机制

植物节律调节的分子机制

教育经历

2011.09-2016.06  中山大学，生命科学学院，理学博士学位

2007.09-2011.06 中山大学，生命科学学院，理学学士学位

工作经历

2021.09 - 至今  中山大学生态学院 “百人计划”副教授

2020.05 - 2021.08，美国北卡罗来纳大学教堂山分校（University of North Carolina at Chapel Hill），病理学及实验室医学系，研究助理教授

2017.05 - 2020.04，美国北卡罗来纳大学教堂山分校（University of North Carolina at Chapel Hill），遗传系，博后研究员

代表论著

近五年代表论文（实验室成员；†，共同第一作者；*，通讯作者）：

Qian, J.†, Wang, N.†, Ren, W.†, Zhang, R., Hong, X., Chen, L., Zhang, K., Shu, Y., Hu, N., Yang, Y.* (2022) Molecular dissection unveiling dwarfing effects of plant growth retardants on pomegranate. Frontiers in Plant Science, 13: 866193. PMID: 35360308.

Wang, H.†, Yang Y.†, Qian, Y., Liu, J., Qian, L. (2022) Delineating Chromatin Accessibility Re-patterning at Single Cell Level during Early Stage of Direct Cardiac Reprogramming. Journal of Molecular and Cellular Cardiology, 162: 62-71. PMID: 34509499.

Wang, L.†, Yang, Y.†, Ma, H., ...., Liu, J., Qian, L. (2022) Single cell dual-omics reveals the transcriptomic and epigenomic diversity of cardiac non-myocytes. Cardiovascular Research, 118, 1548–1563. PMID: 33839759.

Ma, H.†, Liu, Z.†, Yang, Y.†, ..., Welch, J., Qian, L., Liu, J. (2021) Coordinated transcriptome and cell state dynamics of non-myocytes in heart regeneration. EMBO reports, 22: e52901. PMID: 34523214.

Yang, Y., Li, G., Xie, Y., Wang, L., Lagler, T., Yang, Y., Liu, J., Qian, L., Li, Y. (2021) iSMNN: Batch Effect Correction for Single-cell RNA-seq data via Iterative Supervised Mutual Nearest Neighbor Refinement. Briefings in Bioinformatics, 22: bbab122. PMID: 33839756.

Wang, H., Yang, Y., Liu, J., Qian, L. (2021) Direct cell reprogramming: approaches, mechanisms and progress. Nature Reviews Molecular Cell Biology, 22: 410–424. PMID: 33619373.

Yang, Y.†, Li, G.†, Qian, H., Wilhelmsen, K., Shen, Y., Li., Y. (2020) SMNN: Batch Effect Correction for Single-cell RNA-seq data via Supervised Mutual Nearest Neighbor Detection. Briefings in Bioinformatics, 22: bbaa097. PMID: 32591778.

Qian, J., Zhang, X., Yan, Y., Wang, N., Ge, W., Zhou, Q.*, Yang, Y.* (2020) Unravelling the molecular mechanisms of Abscisic acid-mediated drought-stress alleviation in pomegranate (Punica granatum L.). Plant Physiology and Biochemistry, 157: 211-218. PMID: 33120112.

Yang, Y., Li, Y., Sancar, A., Oztas, O. (2020) The circadian clock shapes the Arabidopsis transcriptome through regulating alternative splicing and alternative polyadenylation. Journal of Biological Chemistry, 295: 7608-7619. PMID: 32303634.

Huh, R.†, Yang, Y.†, Jiang, Y., Shen, Y., Li, Y. (2020) SAME-clustering: Single-cell Aggregated Clustering via Mixture Model Ensemble. Nucleic Acids Research, 48: 86-95. PMID: 31777938.

Yang, Y., Huh, R., Culpepper, H., Lin, Y., Love, M., Li, Y. (2019) SAFE-clustering: Single-cell Aggregated (From Ensemble) Clustering for Single-cell RNA-seq Data. Bioinformatics, 35: 1269-1277. PMID: 30202935.

Zhou Q.†, Yang Y.†, Yang Z. (2019) Molecular dissection of cadmium-responsive transcriptome profile in a low-cadmium-accumulating cultivar of Brassica parachinensis. Ecotoxicology and Environmental Safety, 176: 85-94. PMID: 30921700.